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Polo-like kinase : ウィキペディア英語版 | Polo-like kinase Polo-like kinases (Plks) are important regulators of the cell cycle. Plks are involved in the formation of and the changes in the mitotic spindle and in the activation of CDK/cyclin complexes during the M-phase of the cell cycle. Polo-like kinases (Plks) are a family of conserved serine/threonine kinases involved in the regulation of cell cycle progression through G2 and mitosis. Mammalian polo-like kinases include Plk1 (Xenopus Plx1), Plk2/Snk (Xenopus Plx2), Plk3/Prk/FnK (Xenopus Plx3), Plk4/Sak and Plk5. Most species have only one form of Plk; Drosophila (Polo), Schizosaccharomyces pombe (Plo1) and Saccharomyces cerevisiae (Cdc5). Polo-like kinases are involved in aspects of mitosis that include mitotic entry and exit and cytokinesis. ==Structure== The catalytic domain of polo-like kinases is located in the N-terminus. The C-terminus of Plks contains one or two motifs known as polo boxes that help localize the kinase to specific mitotic structures during mitosis. These include the centrosomes in early M phase, the spindle midzone in early and late anaphase and the midbody during cytokinesis.
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